The South African Health Products Regulatory Authority (SAHPRA) is responsible for regulating health products in South Africa, including medicines, medical devices, and radiation control. It offers services such as licensing, registration, and oversight of clinical trials. SAHPRA's target audience includes manufacturers, distributors, and users of health products. Its unique selling proposition is ensuring access to safe, effective, and quality health products through science-based regulatory decisions, aligning with global standards while addressing local health needs[1][2][3]. SAHPRA replaced the Medicines Control Council and Directorate of Radiation Control to streamline health product regulation[1][5].